Regulation of receptor signaling pathway via STAT

Across TCGA cell cohorts, RNA activity of the Regulation of receptor signaling pathway via STAT pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCAF8, RBP5, and CSNK1E, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DCAF8 grouped by Regulation of receptor signaling pathway via STAT-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DCAF8 →	-0.889	-0.996	.003	.008	3	4
LUNG_SCLC	RBP5 →	+1.041	+0.875	.001	<.001	3	3
LUNG_SCLC	CSNK1E →	+0.666	+1.034	.003	.003	3	3
SKIN	GPR62 →	-0.184	-0.921	.002	<.001	3	3
LARGE_INTESTINE	YDJC →	+0.658	+0.703	.002	.008	3	3
KIDNEY	SND1 →	+0.725	+1.310	.004	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DCAF8 by Regulation of receptor signaling pathway via STAT activity — LUNG_NSCLC_LUSC

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