Regulation of receptor signaling pathway via STAT

Across TCGA cell cohorts, RNA activity of the Regulation of receptor signaling pathway via STAT pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZDBF2, BAG3, and HNF4G, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor signaling pathway via STAT activity versus ZDBF2 in BLOOD_Leukemia (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZDBF2 →	+0.822	+0.689	.007	.009	3	4
CNS	BAG3 →	+0.889	+0.307	.003	.001	3	4
SKIN	HNF4G →	+0.605	+0.261	.001	.002	3	4
PANCREAS	EVA1A →	+2.292	+0.213	<.001	.004	3	4
LUNG_SCLC	GPR39 →	+1.275	+0.243	.005	.005	3	4
LUNG_NSCLC_LUSC	MTERF2 →	-1.384	-0.416	.008	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904892 vs ZDBF2 — BLOOD_Leukemia

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