Inhibitory synapse assembly

Across TCGA patient cohorts, RNA activity of the Inhibitory synapse assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASAP1, AP1M2, and HAT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inhibitory synapse assembly activity versus ASAP1 in LSCC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ASAP1 →	+0.189	+0.059	<.001	<.001	3	5
LSCC	AP1M2 →	-0.228	-0.039	.004	.003	3	5
COAD	HAT1 →	+0.326	+0.052	.002	<.001	3	5
COAD	ITGAM →	+0.549	+0.033	.006	.002	3	5
HNSC	BASP1_T36 →	+0.600	+0.070	<.001	<.001	3	5
GBM	KCNAB2_S9 →	+0.484	+0.073	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904862 vs ASAP1 — LSCC

Explore this scatter interactively →