Inhibitory synapse assembly

Across TCGA pan-cancer cohorts, RNA activity of the Inhibitory synapse assembly pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 20 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Inhibitory synapse assembly pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and STAD, show the opposite pattern, with higher activity associated with better survival.

LGG, MESO, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Quartile	All	0.935	0.825	<.001	31	view →
MESO	OS	Tertile	IV	0.144	0.660	<.001	28	view →
STAD	OS	Quartile	All	0.783	0.604	.007	26	view →
UCS	OS	Median	All	0.492	0.219	.006	22	view →
BLCA	OS	Median	II,III,IV	0.775	0.672	.015	22	view →
SKCM	DFS	Median	All	0.671	0.572	.004	21	view →
THYM	DFS	Median	II,III,IV	0.965	0.831	.013	11	view →
KIRP	DFS	Quartile	All	1.000	0.860	.003	11	view →
LUSC	OS	Quartile	All	0.468	0.353	.025	10	view →
PAAD	DFS	Median	II,III,IV	0.348	0.508	.003	9	view →
COAD	OS	Median	All	0.341	0.793	.011	9	view →
ESCA	DFS	Median	IV	0.213	0.626	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:1904862–LGG (OS)

Open the LGG breakdown →