Inhibitory synapse assembly

Across TCGA patient cohorts, RNA activity of the Inhibitory synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIRA, ZBTB18, and LINC02019, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inhibitory synapse assembly activity versus HIRA in HNSC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HIRA →	+0.410	+0.789	.007	<.001	3	4
GBM	ZBTB18 →	+0.951	+0.697	<.001	<.001	3	4
LSCC	LINC02019 →	+0.250	+0.589	.005	.008	3	4
BRCA	RPS27P27 →	+0.622	+0.480	.003	.001	3	4
GBM	LINC01388 →	+0.487	+0.464	.003	.001	3	4
GBM	KRT8P15 →	+0.681	+0.564	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904862 vs HIRA — HNSC

Explore this scatter interactively →