Inhibitory synapse assembly

Across TCGA cell cohorts, RNA activity of the Inhibitory synapse assembly pathway is significantly associated with the total protein of multiple features, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are eIF4G, ER-alpha_pS118, and N-Ras, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inhibitory synapse assembly activity versus eIF4G in BREAST (Pearson r = -1.00).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	eIF4G →	-0.665	-1.722	.020	.033	1	1
BREAST	ER-alpha_pS118 →	+0.919	+1.722	.016	.033	1	1
BREAST	N-Ras →	+0.200	+1.722	.009	.033	1	1
BREAST	p38-MAPK →	+0.543	+1.722	.005	.033	1	1
BREAST	p38 alpha MAPK →	+0.349	+1.722	.041	.033	1	1
BREAST	p90 RSK →	-0.498	-1.722	.013	.033	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904862 vs eIF4G — BREAST

Explore this scatter interactively →