Inhibitory synapse assembly

Across TCGA cell cohorts, RNA activity of the Inhibitory synapse assembly pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Doxorubicin, Etoposide, and Mitomycin-C, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Doxorubicin grouped by Inhibitory synapse assembly-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Doxorubicin →	+1.289	+0.345	.008	.024	3	2
LUNG_SCLC	Etoposide →	+1.353	+0.306	.022	.032	3	2
LUNG_SCLC	Mitomycin-C →	+1.110	+0.431	.002	.008	3	2
LUNG_SCLC	CP466722 →	+0.843	+0.306	.011	.032	3	2
LUNG_SCLC	VNLG/124 →	+0.490	+0.306	.008	.032	3	2
LUNG_SCLC	PD0325901 →	+0.549	+0.431	.010	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Doxorubicin by Inhibitory synapse assembly activity — LUNG_SCLC

Explore this box plot interactively →