"Regulation of protein localization to chromosome, telomeric region"

Across TCGA patient cohorts, RNA activity of the "Regulation of protein localization to chromosome, telomeric region" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1377, PARP1, and SF3B3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of protein localization to chromosome, telomeric region" activity versus TOP2A_S1377 in LSCC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOP2A_S1377 →	+1.083	+0.038	<.001	.002	3	7
HNSC	PARP1 →	+0.625	+0.092	<.001	<.001	3	7
LUAD	SF3B3 →	+0.114	+0.035	.002	.004	3	6
UCEC	STAG2 →	+0.216	+0.106	<.001	<.001	3	6
LSCC	SUPT6H →	+0.199	+0.044	.001	<.001	3	6
HNSC	ADNP →	+0.334	+0.118	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904814 vs TOP2A_S1377 — LSCC

Explore this scatter interactively →