Positive regulation of protein localization to cell cortex

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein localization to cell cortex pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC24D, FKBP10, and ECM2_S213, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to cell cortex activity versus SEC24D in GBM (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEC24D →	-0.313	-0.044	<.001	<.001	3	6
GBM	FKBP10 →	-0.502	-0.065	<.001	<.001	3	6
PDAC	ECM2_S213 →	-0.899	-0.034	<.001	.006	3	6
BRCA	SPARC →	-0.547	-0.052	<.001	<.001	3	5
COAD	EPB41 →	+0.266	+0.053	<.001	<.001	3	5
BRCA	KRT8_S457 →	-1.110	-0.030	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904778 vs SEC24D — GBM

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