Positive regulation of protein localization to cell cortex

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein localization to cell cortex pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPB41L2, GKAP1, and PNISR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to cell cortex activity versus EPB41L2 in UCEC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EPB41L2 →	+1.099	+0.284	<.001	<.001	3	7
LSCC	GKAP1 →	+0.681	+0.282	<.001	<.001	3	6
LSCC	PNISR →	+0.355	+0.265	.002	.005	3	5
LSCC	TMEM170B →	+0.630	+0.349	<.001	<.001	3	5
UCEC	AFF3 →	+1.111	+0.282	<.001	<.001	3	5
CCRCC	PIP4K2A →	+0.225	+0.205	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904778 vs EPB41L2 — UCEC

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