Positive regulation of protein localization to cell cortex

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to cell cortex pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF581, ZMAT5, and KCTD7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF581 grouped by Positive regulation of protein localization to cell cortex-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF581 →	+0.891	+1.217	.001	.009	3	4
OESOPHAGUS	ZMAT5 →	+0.781	+1.255	.005	.007	3	3
OESOPHAGUS	KCTD7 →	+1.115	+1.259	.003	.009	2	4
KIDNEY	GNAZ →	+1.222	+1.476	<.001	.001	3	3
KIDNEY	SLC6A8 →	+2.029	+1.413	.003	.002	3	3
KIDNEY	ZMPSTE24 →	+0.767	+1.182	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF581 by Positive regulation of protein localization to cell cortex activity — SOFT_TISSUE

Explore this box plot interactively →