Positive regulation of protein localization to cell cortex

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to cell cortex pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD99L2, MARK1, and IFT22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to cell cortex activity versus CD99L2 in URINARY_TRACT (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CD99L2 →	+2.020	+0.331	<.001	.005	3	5
OESOPHAGUS	MARK1 →	-2.216	-0.222	<.001	.004	3	4
LIVER	IFT22 →	+1.229	+0.208	.002	.006	3	4
PANCREAS	FCGR1B →	-0.128	-0.257	.007	.002	3	4
SOFT_TISSUE	CEP126 →	+0.859	+0.207	.002	.005	3	4
SKIN	CCN2 →	+2.917	+0.277	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904778 vs CD99L2 — URINARY_TRACT

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