Regulation of protein localization to cell cortex

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to cell cortex pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM178A, TMEM246-AS1, and RPGRIP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to cell cortex activity versus TMEM178A in UCEC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM178A →	+1.058	+0.238	.001	<.001	3	4
GBM	TMEM246-AS1 →	+0.727	+0.263	.003	<.001	3	4
GBM	RPGRIP1 →	+0.259	+0.253	.004	<.001	3	4
OV	ATP5MC2P3 →	+0.498	+0.444	<.001	.002	3	4
COAD	NPM1P33 →	+0.080	+0.144	.009	.008	3	3
HNSC	CRACD →	+0.813	+0.721	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904776 vs TMEM178A — UCEC

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