Regulation of protein localization to cell cortex

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to cell cortex pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MUTYH, HIRA, and HS1BP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MUTYH grouped by Regulation of protein localization to cell cortex-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MUTYH →	+0.713	+0.204	.001	.001	3	4
LUNG_NSCLC_LUAD	HIRA →	+0.692	+0.334	.001	.005	3	4
SOFT_TISSUE	HS1BP3 →	+0.987	+0.378	.005	.008	2	5
BLOOD_Lymphoma	IQCN →	+0.922	+0.357	.002	.001	3	4
LARGE_INTESTINE	RNMT →	+0.613	+0.225	.001	.001	3	4
KIDNEY	DGKE →	-1.297	-0.751	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MUTYH by Regulation of protein localization to cell cortex activity — LARGE_INTESTINE

Explore this box plot interactively →