Regulation of myofibroblast differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of myofibroblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAF12, SERBP1, and SH3BGRL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myofibroblast differentiation activity versus TAF12 in BRCA (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TAF12 →	-0.194	-0.085	.008	<.001	3	5
OV	SERBP1 →	-0.270	-0.097	.001	<.001	3	5
HNSC	SH3BGRL2 →	+0.315	+0.071	<.001	<.001	3	5
BRCA	SORBS3 →	+0.314	+0.062	<.001	<.001	3	5
BRCA	SYNPO2_S930 →	+0.624	+0.088	<.001	<.001	3	5
LUAD	STIP1_S481 →	-0.388	-0.051	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904760 vs TAF12 — BRCA

Explore this scatter interactively →