Regulation of myofibroblast differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of myofibroblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNIP1, TPRA1, and EXPH5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNIP1 grouped by Regulation of myofibroblast differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TNIP1 →	+2.278	+1.572	<.001	.001	3	5
LUNG_SCLC	TPRA1 →	+0.663	+1.070	<.001	.002	3	5
LUNG_NSCLC_LUAD	EXPH5 →	+0.958	+0.733	.003	.005	3	4
OVARY	TMEM51 →	+0.988	+0.818	<.001	.002	3	4
OVARY	SVIP →	+1.534	+0.897	<.001	.003	3	4
SOFT_TISSUE	FOXP1 →	+1.940	+0.968	.004	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNIP1 by Regulation of myofibroblast differentiation activity — SOFT_TISSUE

Explore this box plot interactively →