Regulation of myofibroblast differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of myofibroblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WIPI1, GOLGA8R, and ZNF551, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myofibroblast differentiation activity versus WIPI1 in OVARY (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	WIPI1 →	-1.369	-0.175	.006	.002	3	4
BREAST	GOLGA8R →	+0.967	+0.378	.003	.005	3	4
CNS	ZNF551 →	+0.772	+0.284	.004	.006	3	4
BLOOD_Lymphoma	HMOX1 →	-1.907	-0.202	.003	<.001	3	4
BLOOD_Lymphoma	STARD3 →	-0.779	-0.254	<.001	.001	3	4
BLOOD_Leukemia	IL32 →	-3.095	-0.175	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904760 vs WIPI1 — OVARY

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