Positive regulation of vascular associated smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAX, PLRG1, and F7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAX grouped by Positive regulation of vascular associated smooth muscle cell migration-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAX →	-0.525	-0.198	<.001	.001	3	5
LARGE_INTESTINE	PLRG1 →	-0.505	-0.096	<.001	<.001	3	4
LUNG_NSCLC_LUSC	F7 →	-0.227	-0.146	.006	.001	3	4
BLOOD_Myeloma	DHRSX →	-0.255	-0.109	.002	.004	3	4
UPPER_AERODIGESTIVE_TRACT	MMD →	+0.207	+0.144	.007	.001	3	4
OESOPHAGUS	MLH3 →	+0.136	+0.173	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAX by Positive regulation of vascular associated smooth muscle cell migration activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →