Positive regulation of apoptotic process involved in development

Across TCGA patient cohorts, RNA activity of the Positive regulation of apoptotic process involved in development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA1755, HSPA8P15, and RNA5SP80, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of apoptotic process involved in development activity versus KIAA1755 in CCRCC (Pearson r = 0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KIAA1755 →	+0.454	+0.653	.003	.002	3	3
CCRCC	HSPA8P15 →	+0.600	+0.691	<.001	<.001	3	3
CCRCC	RNA5SP80 →	+0.792	+0.673	<.001	.004	3	3
CCRCC	RN7SL338P →	+0.507	+0.627	.007	.001	3	3
CCRCC	RRN3P3 →	+0.249	+0.604	.004	<.001	3	3
COAD	GHRL →	+0.282	+0.251	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904747 vs KIAA1755 — CCRCC

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