Positive regulation of apoptotic process involved in development

Across TCGA cell cohorts, RNA activity of the Positive regulation of apoptotic process involved in development pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR61, GATA3, and LRWD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR61 grouped by Positive regulation of apoptotic process involved in development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WDR61 →	-0.541	-0.157	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	GATA3 →	+0.180	+0.168	.002	.003	3	3
UPPER_AERODIGESTIVE_TRACT	LRWD1 →	+0.346	+0.253	.005	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	NBR1 →	+0.108	+0.144	.002	.006	3	3
URINARY_TRACT	POU3F3 →	+0.188	+0.162	.002	.005	3	3
UPPER_AERODIGESTIVE_TRACT	CYP21A2 →	-0.180	-0.177	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR61 by Positive regulation of apoptotic process involved in development activity — BLOOD_Leukemia

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