Positive regulation of vascular associated smooth muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJA1, ENO2, and P3H1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular associated smooth muscle cell proliferation activity versus GJA1 in LSCC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GJA1 →	+1.254	+1.008	<.001	<.001	3	5
LSCC	ENO2 →	+0.705	+0.759	<.001	<.001	3	4
LSCC	P3H1 →	+0.425	+0.814	.003	.001	3	4
UCEC	SPARC →	+0.804	+0.893	<.001	.002	3	4
UCEC	LSM1P1 →	+0.957	+0.720	.001	.006	3	4
LSCC	MXRA5 →	+0.736	+0.677	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904707 vs GJA1 — LSCC

Explore this scatter interactively →