Positive regulation of cytoplasmic translational initiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of cytoplasmic translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC14B, NCLN, and ZNF408, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytoplasmic translational initiation activity versus LRRC14B in GBM (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LRRC14B →	-0.232	-0.860	<.001	.005	3	4
LUAD	NCLN →	-0.255	-0.457	.004	.002	3	4
OV	ZNF408 →	-0.366	-0.135	.003	.001	2	4
GBM	CPSF4 →	-0.416	-0.864	.002	.006	2	4
LUAD	MYBL2 →	-0.984	-0.523	.001	.001	3	3
LUAD	E2F1 →	-0.677	-0.615	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904690 vs LRRC14B — GBM

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