Positive regulation of cytoplasmic translational initiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytoplasmic translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1H, BANK1, and C1orf174, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPM1H grouped by Positive regulation of cytoplasmic translational initiation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PPM1H →	-0.945	-0.185	<.001	.008	3	4
BLOOD_Lymphoma	BANK1 →	+3.997	+0.505	<.001	.001	3	4
BREAST	C1orf174 →	-0.667	-0.826	.002	.006	3	4
BREAST	BAHCC1 →	-1.908	-1.202	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PTK6 →	-1.503	-1.144	.001	.001	3	4
BONE	AJM1 →	-0.715	-0.337	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPM1H by Positive regulation of cytoplasmic translational initiation activity — KIDNEY

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