Regulation of somatic stem cell population maintenance

Across TCGA patient cohorts, RNA activity of the Regulation of somatic stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A33, TRAP1, and FAM27C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of somatic stem cell population maintenance activity versus SLC25A33 in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC25A33 →	+0.519	+0.654	.001	.001	3	4
CCRCC	TRAP1 →	+0.578	+0.260	<.001	.004	3	4
LSCC	FAM27C →	+0.127	+0.701	<.001	<.001	3	4
LSCC	KEAP1 →	+0.623	+0.612	<.001	<.001	3	4
PDAC	RPP14 →	+0.191	+0.211	.002	<.001	3	4
PDAC	MTND5P15 →	+0.465	+0.176	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904672 vs SLC25A33 — BRCA

Explore this scatter interactively →