Positive regulation of ubiquitin protein ligase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of ubiquitin protein ligase activity pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, CSTF3, and SRPK1_S311, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ubiquitin protein ligase activity activity versus SMC2 in LUAD (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SMC2 →	+0.618	+0.111	<.001	<.001	3	9
LSCC	CSTF3 →	+0.194	+0.049	<.001	<.001	3	9
LSCC	SRPK1_S311 →	+0.497	+0.066	<.001	<.001	3	9
LUAD	RSF1_S1282 →	+0.721	+0.065	<.001	<.001	3	8
LUAD	CENPF_S3079 →	+1.106	+0.116	<.001	<.001	3	8
LSCC	REXO4 →	+0.418	+0.061	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904668 vs SMC2 — LUAD

Explore this scatter interactively →