Positive regulation of ubiquitin protein ligase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of ubiquitin protein ligase activity pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC20, CKAP2L, and MCM10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ubiquitin protein ligase activity activity versus CDC20 in UCEC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDC20 →	+1.063	+0.354	<.001	<.001	3	7
GBM	CKAP2L →	+0.883	+0.737	<.001	<.001	3	7
LSCC	MCM10 →	+1.030	+0.262	<.001	<.001	3	7
GBM	DBF4 →	+0.729	+0.765	<.001	<.001	3	7
LSCC	CENPN →	+0.580	+0.221	<.001	<.001	3	7
BRCA	MYBL2 →	+1.150	+0.167	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904668 vs CDC20 — UCEC

Explore this scatter interactively →