Positive regulation of ubiquitin protein ligase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of ubiquitin protein ligase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIBC2, PSMG1, and KATNA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RIBC2 grouped by Positive regulation of ubiquitin protein ligase activity-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RIBC2 →	-1.155	-0.443	.002	.006	3	4
BLOOD_Leukemia	PSMG1 →	+0.833	+0.441	.001	.006	3	4
CNS	KATNA1 →	+0.429	+0.512	.003	.007	3	4
STOMACH	CDC40 →	+0.637	+0.183	.004	.003	2	5
LUNG_NSCLC_LUAD	PYCR3 →	-0.642	-0.277	.001	.001	3	3
LUNG_NSCLC_LUAD	CCND1 →	-0.883	-0.289	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RIBC2 by Positive regulation of ubiquitin protein ligase activity activity — BLOOD_Leukemia

Explore this box plot interactively →