Positive regulation of ubiquitin protein ligase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of ubiquitin protein ligase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF214, PRRG4, and GRHL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ubiquitin protein ligase activity activity versus ZNF214 in LUNG_SCLC (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF214 →	-1.571	-1.221	.001	.004	3	4
BREAST	PRRG4 →	-2.848	-1.306	<.001	.009	3	4
BREAST	GRHL2 →	-3.816	-1.780	.003	<.001	3	4
BLOOD_Lymphoma	PARP4 →	-1.002	-0.972	<.001	<.001	3	4
BLOOD_Leukemia	ST14 →	-1.999	-0.929	<.001	.001	3	4
LUNG_SCLC	TRADD →	-0.893	-1.255	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904668 vs ZNF214 — LUNG_SCLC

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