Negative regulation of ubiquitin protein ligase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of ubiquitin protein ligase activity pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOX1, TPP1, and ZNFX1, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ubiquitin protein ligase activity activity versus ACOX1 in KICH (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	ACOX1 →	-0.766	-0.080	<.001	<.001	3	24
PCPG	TPP1 →	-0.935	-0.036	<.001	<.001	3	24
OV	ZNFX1 →	-0.680	-0.037	<.001	<.001	3	23
KICH	MAN2B2 →	-0.891	-0.064	<.001	<.001	2	24
KICH	TMEM127 →	-0.884	-0.077	<.001	<.001	2	24
THYM	CRIM1 →	-1.682	-0.052	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904667 vs ACOX1 — KICH

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