Regulation of ubiquitin protein ligase activity

Across TCGA cell cohorts, RNA activity of the Regulation of ubiquitin protein ligase activity pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2CD2L, ZC3H7B, and APP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C2CD2L grouped by Regulation of ubiquitin protein ligase activity-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C2CD2L →	-0.822	-0.208	<.001	.001	3	5
LARGE_INTESTINE	ZC3H7B →	-0.823	-0.155	.005	.004	3	5
LUNG_NSCLC_LUAD	APP →	-0.543	-0.151	.003	.004	3	3
BREAST	PANK4 →	-0.670	-0.145	.008	.001	2	4
LUNG_NSCLC_LUAD	CYHR1 →	-0.790	-0.182	.001	.002	3	3
LUNG_NSCLC_LUAD	GPAA1 →	-0.807	-0.182	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C2CD2L by Regulation of ubiquitin protein ligase activity activity — SKIN

Explore this box plot interactively →