Response to amyloid-beta

Across TCGA patient cohorts, RNA activity of the Response to amyloid-beta pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS4, GREM2, and REXO5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to amyloid-beta activity versus RGS4 in GBM (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RGS4 →	+1.055	+0.280	.001	<.001	3	5
GBM	GREM2 →	+0.772	+0.444	<.001	<.001	3	5
LSCC	REXO5 →	-0.547	-0.288	<.001	<.001	3	5
OV	KLHDC9 →	-0.601	-0.195	.005	.005	3	4
UCEC	MCM4 →	-0.668	-0.383	<.001	.002	3	4
LSCC	TTK →	-0.608	-0.237	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904645 vs RGS4 — GBM

Explore this scatter interactively →