Response to amyloid-beta

Across TCGA pan-cancer cohorts, RNA activity of the Response to amyloid-beta pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 55 member genes.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher Response to amyloid-beta pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and CHOL, show the opposite pattern, with higher activity associated with better survival.

STAD, UCS, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Quartile	All	0.415	0.768	.001	64	view →
UCS	DFS	Quartile	II,III,IV	0.702	0.242	.006	52	view →
LGG	DFS	Tertile	All	0.678	0.841	<.001	37	view →
GBM	OS	Quartile	All	0.216	0.518	<.001	33	view →
ACC	DFS	Median	All	0.277	0.660	.021	29	view →
CHOL	OS	Tertile	All	0.903	0.373	.006	29	view →
SCLC	DFS	Tertile	All	0.572	0.261	.003	22	view →
UCEC	DFS	Quartile	All	0.590	0.802	.002	18	view →
SKCM	DFS	Median	II,III,IV	0.389	0.171	.022	16	view →
HNSC	DFS	Quartile	II,III,IV	0.470	0.260	.013	10	view →
UVM	OS	Median	All	1.000	0.507	.017	10	view →
LUSC	OS	Median	All	0.718	0.889	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:1904645–STAD (OS)

Open the STAD breakdown →