Response to amyloid-beta

Across TCGA cell cohorts, RNA activity of the Response to amyloid-beta pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM81A, APOBEC3F, and EIF5A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to amyloid-beta activity versus FAM81A in STOMACH (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FAM81A →	-2.075	-0.999	.007	.008	3	4
SKIN	APOBEC3F →	+0.782	+0.163	.008	.007	3	4
LUNG_NSCLC_LUAD	EIF5A2 →	+1.178	+0.386	<.001	.007	3	3
SOFT_TISSUE	VANGL2 →	+3.110	+0.255	<.001	<.001	3	3
LUNG_SCLC	PRPF6 →	+0.666	+0.181	.003	.004	3	3
STOMACH	TSPAN8 →	-5.505	-0.678	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904645 vs FAM81A — STOMACH

Explore this scatter interactively →