Regulation of telomere maintenance in response to DNA damage

Across TCGA patient cohorts, RNA activity of the Regulation of telomere maintenance in response to DNA damage pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RTN1_S352, CGNL1_S283, and SURF2_S59, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of telomere maintenance in response to DNA damage activity versus RTN1_S352 in LSCC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RTN1_S352 →	+0.818	+0.049	<.001	<.001	3	4
GBM	CGNL1_S283 →	-0.364	-0.042	.003	.001	3	4
UCEC	SURF2_S59 →	-0.439	-0.075	.008	.004	3	4
OV	RELB_S573 →	+0.903	+0.049	<.001	<.001	3	3
LUAD	RUVBL1 →	+0.185	+0.049	.004	<.001	3	3
CCRCC	CAVIN2_S344 →	-0.326	-0.023	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904505 vs RTN1_S352 — LSCC

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