Regulation of telomere maintenance in response to DNA damage

Across TCGA cell cohorts, RNA activity of the Regulation of telomere maintenance in response to DNA damage pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTEL1, POLD1, and ACTR8, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of telomere maintenance in response to DNA damage activity versus RTEL1 in URINARY_TRACT (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RTEL1 →	+1.454	+0.123	<.001	<.001	3	17
OESOPHAGUS	POLD1 →	+1.362	+0.126	<.001	.001	3	16
LUNG_SCLC	ACTR8 →	+0.907	+0.108	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DHX30 →	+0.833	+0.078	.001	.001	2	14
UPPER_AERODIGESTIVE_TRACT	BRPF1 →	+1.168	+0.074	<.001	.003	1	15
URINARY_TRACT	TFPT →	+1.080	+0.084	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904505 vs RTEL1 — URINARY_TRACT

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