Regulation of lipophagy

Across TCGA patient cohorts, RNA activity of the Regulation of lipophagy pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP25, ATP5IF1, and TTI1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipophagy activity versus UTP25 in LSCC (Pearson r = -0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UTP25 →	-0.535	-0.094	<.001	<.001	3	7
GBM	ATP5IF1 →	+0.388	+0.074	.006	.006	3	6
GBM	TTI1 →	-0.285	-0.105	<.001	<.001	3	6
GBM	URB2 →	-0.245	-0.067	<.001	.002	3	6
LSCC	UTP15 →	-0.251	-0.077	<.001	<.001	3	6
LSCC	DDX18 →	-0.308	-0.070	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904502 vs UTP25 — LSCC

Explore this scatter interactively →