Regulation of lipophagy

Across TCGA patient cohorts, RNA activity of the Regulation of lipophagy pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FABP5P9, VIM, and MRFAP1L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipophagy activity versus FABP5P9 in GBM (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FABP5P9 →	-0.629	-0.217	<.001	<.001	3	4
GBM	VIM →	-0.456	-0.177	.006	.004	3	3
LUAD	MRFAP1L1 →	+0.248	+0.184	.004	.007	3	3
COAD	LATS2 →	-0.532	-0.242	<.001	.002	3	3
COAD	NPR1 →	-0.440	-0.205	<.001	.009	3	3
CCRCC	SUSD6 →	-0.419	-0.346	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904502 vs FABP5P9 — GBM

Explore this scatter interactively →