Regulation of matrix metallopeptidase secretion

Across TCGA cell cohorts, RNA activity of the Regulation of matrix metallopeptidase secretion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDH2, ZNF710, and SMIM22, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of matrix metallopeptidase secretion activity versus IDH2 in BLOOD_Myeloma (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	IDH2 →	+3.930	+0.383	<.001	<.001	3	12
LARGE_INTESTINE	ZNF710 →	+0.478	+0.233	.004	<.001	3	6
LARGE_INTESTINE	SMIM22 →	+1.902	+0.201	.006	.002	3	6
STOMACH	CHDH →	+1.631	+0.217	.004	.006	3	5
STOMACH	IL17RB →	+2.261	+0.210	.001	.008	3	5
KIDNEY	FAAH →	+1.917	+0.173	.002	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904464 vs IDH2 — BLOOD_Myeloma

Explore this scatter interactively →