Positive regulation of calcium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of calcium ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP4, VAMP5, and WARS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion transmembrane transport activity versus GBP4 in LSCC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GBP4 →	+0.606	+0.044	<.001	<.001	3	9
GBM	VAMP5 →	+0.505	+0.057	<.001	<.001	3	8
LSCC	WARS1 →	+0.716	+0.043	<.001	<.001	3	8
LSCC	PSMB6 →	-0.491	-0.040	<.001	<.001	3	8
HNSC	CD163 →	+0.681	+0.051	<.001	<.001	3	7
LSCC	SAMSN1_S107 →	+0.744	+0.045	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904427 vs GBP4 — LSCC

Explore this scatter interactively →