Regulation of xenophagy

Across TCGA cell cohorts, RNA activity of the Regulation of xenophagy pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP2, FAM72C, and RABGGTA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of xenophagy activity versus USP2 in LIVER (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	USP2 →	+1.047	+0.234	.001	<.001	3	4
PANCREAS	FAM72C →	+0.956	+0.181	.005	.007	3	3
BLOOD_Leukemia	RABGGTA →	-0.480	-0.157	<.001	.001	3	3
LUNG_SCLC	SRP54 →	-1.060	-0.228	.001	.003	3	3
LUNG_SCLC	C14orf28 →	-0.553	-0.187	<.001	.003	3	3
LUNG_SCLC	TBC1D2 →	-1.020	-0.290	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904415 vs USP2 — LIVER

Explore this scatter interactively →