Regulation of neuromuscular junction development

Across TCGA patient cohorts, RNA activity of the Regulation of neuromuscular junction development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BAG2, EPB41L2, and HSPH1_S809, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuromuscular junction development activity versus BAG2 in CCRCC (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BAG2 →	-0.854	-0.093	<.001	<.001	3	6
LSCC	EPB41L2 →	-0.270	-0.101	<.001	<.001	3	5
PDAC	HSPH1_S809 →	+0.488	+0.063	<.001	<.001	3	5
BRCA	TGFB1 →	-0.319	-0.063	.001	<.001	3	5
CCRCC	ELMO2 →	-0.238	-0.099	<.001	<.001	3	5
LSCC	CYLD →	-0.287	-0.108	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904396 vs BAG2 — CCRCC

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