Response to L-phenylalanine derivative

Across TCGA patient cohorts, RNA activity of the Response to L-phenylalanine derivative pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GCLM, GCLC, and AKR1C3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to L-phenylalanine derivative activity versus GCLM in LSCC (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GCLM →	+1.159	+0.164	<.001	<.001	3	10
LSCC	GCLC →	+1.103	+0.140	<.001	<.001	3	7
LSCC	AKR1C3 →	+1.441	+0.116	<.001	<.001	3	6
LSCC	GCLC_S8 →	+1.227	+0.143	<.001	<.001	3	6
LSCC	SRXN1 →	+1.223	+0.117	<.001	<.001	3	5
LUAD	FAM118B →	-0.297	-0.073	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904386 vs GCLM — LSCC

Explore this scatter interactively →