Response to L-phenylalanine derivative

Across TCGA patient cohorts, RNA activity of the Response to L-phenylalanine derivative pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAAF5, TNRC18, and TRMT112P2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to L-phenylalanine derivative activity versus DNAAF5 in HNSC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DNAAF5 →	-0.673	-0.183	.001	.002	3	3
OV	TNRC18 →	-1.057	-0.105	.005	.009	3	3
HNSC	TRMT112P2 →	-0.446	-0.173	<.001	<.001	3	3
LSCC	HCK →	+0.611	+0.168	.002	<.001	3	3
BRCA	AKAP9 →	-0.519	-0.129	.005	.001	3	3
BRCA	ERVW-1 →	-0.191	-0.152	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904386 vs DNAAF5 — HNSC

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