Response to sodium phosphate

Across TCGA patient cohorts, RNA activity of the Response to sodium phosphate pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALPL, FGF14, and CDC42BPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sodium phosphate activity versus ALPL in UCEC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ALPL →	+1.963	+0.212	<.001	<.001	3	5
PDAC	FGF14 →	-0.538	-0.454	.002	<.001	3	3
PDAC	CDC42BPA →	-0.329	-0.345	.003	.001	3	3
PDAC	ITIH3 →	-0.586	-0.480	<.001	<.001	3	3
UCEC	GRIN3A →	-0.267	-0.126	.003	.008	3	3
UCEC	USH2A →	-0.469	-0.198	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904383 vs ALPL — UCEC

Explore this scatter interactively →