Response to sodium phosphate

Across TCGA cell cohorts, RNA activity of the Response to sodium phosphate pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FEM1A, HLA-F, and NRDE2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FEM1A grouped by Response to sodium phosphate-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FEM1A →	-0.400	-1.311	.003	<.001	3	4
OVARY	HLA-F →	+2.220	+1.146	.002	.001	3	4
SOFT_TISSUE	NRDE2 →	-0.869	-1.495	.002	<.001	3	4
OVARY	ANAPC15 →	+0.785	+1.029	.002	.005	3	4
OVARY	UAP1 →	+1.240	+1.240	<.001	<.001	3	4
BLOOD_Leukemia	ZNF92 →	+0.965	+1.151	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FEM1A by Response to sodium phosphate activity — PANCREAS

Explore this box plot interactively →