Regulation of protein localization to cell periphery

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to cell periphery pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKG1, RPL11, and RPL5, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to cell periphery activity versus PRKG1 in CCRCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PRKG1 →	+0.574	+0.038	<.001	<.001	3	10
LSCC	RPL11 →	-0.136	-0.028	.003	.005	3	8
OV	RPL5 →	-0.230	-0.037	<.001	.001	3	8
LSCC	CLPX →	-0.328	-0.032	<.001	.001	3	8
OV	CYGB →	+0.559	+0.035	.002	<.001	3	8
OV	HAAO →	+0.457	+0.029	.002	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904375 vs PRKG1 — CCRCC

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