Regulation of protein localization to cell periphery

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to cell periphery pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS6KA2, SLC37A1, and BIK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS6KA2 grouped by Regulation of protein localization to cell periphery-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPS6KA2 →	+1.875	+0.157	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	SLC37A1 →	+1.179	+0.167	.007	<.001	3	6
SKIN	BIK →	+0.980	+0.168	.001	<.001	3	5
SKIN	SLC27A5 →	+1.216	+0.123	.006	.009	3	5
BREAST	NDST2 →	-0.645	-0.118	<.001	<.001	3	5
PANCREAS	LIPG →	+3.114	+0.217	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS6KA2 by Regulation of protein localization to cell periphery activity — LUNG_NSCLC_LUAD

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