Positive regulation of telomere capping

Across TCGA patient cohorts, RNA activity of the Positive regulation of telomere capping pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP36_S73, NCAPG_S674, and CHEK1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of telomere capping activity versus RRP36_S73 in UCEC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRP36_S73 →	+0.881	+0.083	<.001	<.001	3	8
GBM	NCAPG_S674 →	+0.860	+0.074	<.001	<.001	3	8
GBM	CHEK1 →	+0.500	+0.055	<.001	<.001	3	8
PDAC	RFC1_T506 →	+0.990	+0.068	<.001	<.001	3	7
UCEC	RFC4 →	+0.444	+0.109	<.001	<.001	3	7
PDAC	RFC5 →	+0.254	+0.061	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904355 vs RRP36_S73 — UCEC

Explore this scatter interactively →