Regulation of telomere capping

Across TCGA patient cohorts, RNA activity of the Regulation of telomere capping pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_T506, DNMT1, and TOP2A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of telomere capping activity versus RFC1_T506 in LUAD (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC1_T506 →	+0.982	+0.051	<.001	<.001	3	7
UCEC	DNMT1 →	+0.320	+0.057	.005	.002	3	7
LUAD	TOP2A →	+0.829	+0.035	<.001	<.001	3	7
LUAD	MKI67 →	+0.565	+0.036	<.001	<.001	3	7
BRCA	RFC2 →	+0.291	+0.022	<.001	.002	3	6
PDAC	SMARCE1 →	+0.134	+0.029	.008	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904353 vs RFC1_T506 — LUAD

Explore this scatter interactively →