Regulation of telomere capping

Across TCGA cell cohorts, RNA activity of the Regulation of telomere capping pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIG1, COX14, and UAP1L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of telomere capping activity versus LIG1 in URINARY_TRACT (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LIG1 →	+1.367	+0.343	.003	.006	3	5
URINARY_TRACT	COX14 →	+0.607	+0.261	.001	.002	3	4
LUNG_SCLC	UAP1L1 →	-0.774	-0.160	.002	<.001	3	4
BREAST	PEX11B →	+0.618	+0.160	.005	.006	3	4
BREAST	BCKDHA →	+1.274	+0.265	.001	.003	3	4
BREAST	MTMR1 →	+0.719	+0.220	.002	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904353 vs LIG1 — URINARY_TRACT

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